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Olfaction and Memory

Team Leader : Lisa Roux

Biosketch HERE

 

General objective

Chemosensation is a fundamental sensory modality for living organisms, ranging from Bacteria to Mammals. It is used for many vital functions such as spatial navigation and communication with conspecifics. Odors can trigger innate behavioral responses, but most odor stimuli acquire behavioral significance upon learning and experience. The overarching goal of our team is to identify the neurophysiological substrates of olfactory memory formation across distributed brain networks.

To reach this goal, we study rodents in naturalistic conditions using cutting-edge technologies that allow recording and manipulating large neuronal ensembles in behaving animals: single unit extracellular recordings with silicon probes, closed-loop optogenetic strategies, automated behavioral tracking and precise monitoring of sniffing behavior.

Research Projects

Olfaction in spatial learning

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Olfaction in social recognition memory

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Role of oxytocin in the piriform cortex

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Expertise

  • Multi-electrode recordings in freely moving mice (silicon probes, tetrodes)
  • Optogenetics
  • Behavioral Assays (navigation, social behaviors...)
  • Stereotaxic surgeries (electrode implants, viral injections, canula placement)
  • In vivo pharmacology
  • Analysis of neuronal population datasets (LFP, spikes)
  • News

    Lisa interviewed for article in Horizon Magazine

    On the role of social scents. Article by Alex Whiting.

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    Lisa and Pascal contributed to "L'Enquête des Sens"

    Chaque année, les étudiant·es du master Médiation des sciences de Bordeaux et l’association Dealers de Sciences organisent une semaine de culture scientifique et technique. Pour sa 5ème édition, la thématique choisie est « L’Enquête des Sens ». Lisa Roux et Pascal Ravassard ont répondu aux questions de leur interviewers sur la perception olfactive (https://www.lenquetedessens.dealersdescience.com/index.php/2020/10/03/les-serrures-de-lodorat/) et le lien entre mémoire et odorat (https://www.lenquetedessens.dealersdescience.com/index.php/2020/11/08/les-echos-de-la-memoire/).

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    Lisa Roux laureate of the Fondation Schlumberger pour l'Education et la Recherche

    The Schlumberger Foundation for Education and Research selects each year three laureates amongst the best young researchers who are building their team in the field of life sciences. A group leader of IINS, Lisa Roux, is one of the laureates in 2021. She has just received a prize to support the establishment of her team and will join the Cercle FSER in taking action to defend and highlight the value of basic science research.

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    Evan Harrell is joining the team with an IdEx Junior Chair of Bordeaux University

    Congratulations to him!

    Lisa will give a talk at the 3rd Science and Gender Equality Symposium “SAGE 3.0”

    Dates: October 21-22, 2021 on ZOOM (registration required). The symposium is funded by the DFG Collaborative Research Center 936 (SFB 936). To know more, follow the link below.

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    Selected Publications

  • Roux L, Hu B, Eichler R, Stark E, Buzsáki G
  • Sharp wave ripples during learning stabilize the hippocampal spatial map Nature Neuroscience (2017)
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  • Stark E., Roux L., Eichler R., Buzsáki G.
  • Local generation of multi-neuronal spike sequences in the hippocampal CA1 region. PNAS (2015)
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  • Roux L., Madar A., Lacroix MM, Chenju Y., Benchenane K., Giaume C.
  • Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations. Journal of Neuroscience (2015)
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  • Stark E*, Roux L*, Eichler R*, Senzai Y, Royer S, Buzsáki G (*equal contribution)
  • Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations. Neuron (2014)
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  • Roux L., Benchenane K., Rothstein J., Bovento G., Giaume C.
  • Plasticity of astroglial networks in the olfactory glomeruli. PNAS (2011)
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    Members

    « Researcher »

    HARRELL Evan Researcher evan.harrell@u-bordeaux.fr +33533514700
    ROUX Lisa Researcher lisa.roux@u-bordeaux.fr +33533514851

    « Technical Staff »

    CADORET Marie-Anne Technical staff marie-anne.cadoret@u-bordeaux.fr +33533514701
    DOLIQUE Tiphaine Technical staff tiphaine.dolique@u-bordeaux.fr +33533514852

    « Postdoc »

    CASALI Giulio Postdoc giulio.casali@u-bordeaux.fr +33533514852
    RAVASSARD Pascal Postdoc pascal.ravassard@u-bordeaux.fr +33533514700
    TERRAL Geoffrey Postdoc geoffrey.terral@u-bordeaux.fr +33533514752

    « PhD student »

    MIERMON Camille PhD student camille.miermon@etu.u-bordeaux.fr +33533514752
    SPITSYN Aléna PhD student alena.spitsyn@u-bordeaux.fr +33533514852

    « Alumni & Guests »

    • Tessa Scarabello, Master 1 student, NeuroBIM (2021)
    • Rafaël Michaud, Master 1 student, NeuroBIM (2021)
    • Edith Lesburguères, postdoc (2018-2020)
    • Léonie Henry, student (2020)
    • Louis Ware, student, Ecole Santé-Science de Bordeaux (2018)

    Jobs

    The team is hiring!

    Open postdoctoral position on ERC SociOlfa project. Motivated candidates can send their application and CV to: lisa.roux@u-bordeaux.fr

    Fundings

    Bordeaux Neurocampus
    IdEx of Bordeaux University
    ATIP-Avenir
    ERC Starting Grant: SociOlfa