Team THOUMINE : Postdoc position in Cellular Neuroscience 2023-01-05
We are hiring one highly motivated postdoctoral scientist to investigate the molecular, structural and functional organization of the glutamatergic tripartite synapse. In light of recent evidence that astrocytes are not just a mere "glue" surrounding neurons but actively regulate synaptic connections, we want to investigate the molecular interactions that drive and maintain astrocytic processes in close contact with neurons and how those interactions dynamically regulate the structure and plasticity of synapses. To address this question, we will combine whole patch-clamp recordings with single-cell RNA seq (“patch-seq”), proteomics, electrophysiology, expansion microscopy and live microscopy in the mouse hippocampus, where the role of astrocytes in synaptic plasticity is well established. We will further assess the impact of autistic mutations targeting astrocytic protein candidates that have been so far considered only from a neurocentric point of view.
For this project, the candidate should have expertise in either patch-clamp electrophysiology or microscopy and show strong interest in molecular and cellular neuroscience with a focus on neurotransmission and synaptic plasticity. The project is to be developed in the team Cell Adhesion Molecules in Synapse Assembly at IINS of the Bordeaux Neurocampus. The position has 2 years initial funding from ANR.