Research Projects

3D high- and super-resolution imaging at different scales

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Quantitative analysis of super-resolution data

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Single-molecule-based High Content Screening

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Correlative platform for SMLM & STED nanoscopy

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High-content screening imaging of living organoids

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Combining deep-learning with geometric and image processing for analysis of microscopy data

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Expertise

Single-Molecule Localization Microscopy

Light-Sheet Fluorescence Microscopy

High Content Screening

Bioimage Analysis

Geometry Processing

Deep Learning

Selected Publications

F. Levet, J. Tonnesen, U.V. Nagerl, J.B. Sibarita

SpineJ: A software tool for quantitative analysis of nanoscale spine morphology Methods (2020)
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S. Kedia, P. Ramakrishna, P.R. Netrakanti, M. Jose, J.B. Sibarita, S. Nadkarni, D. Nair

Real-time nanoscale organization of amyloid precursor protein Nanoscale (2020)
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D. Jullie, M. Stoeber, J.B. Sibarita, H.L. Zieger, T.M. Bartol, S. Arttamangkul, T.J. Sejnowski, E. Hosy, M. von Zastrow

A Discrete Presynaptic Vesicle Cycle for Neuromodulator Receptors Neuron (2020)
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J. Goncalves, T.M. Bartol, C. Camus, F. Levet, A.P. Menegolla, T.J. Sejnowski, J.B. Sibarita, M. Vivaudou, D. Choquet, E. Hosy

Nanoscale co-organization and coactivation of AMPAR, NMDAR, and mGluR at excitatory synapses PNAS (Proceedings of the National Academy of Sciences) (2020)
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J.S. Ferreira, J.P. Dupuis, B. Kellermayer, N. Benac, C. Manso, D. Bouchet, F. Levet, C. Butler, J.B. Sibarita, L. Groc

Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites PNAS (Proceedings of the National Academy of Sciences) (2020)
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E. Dondi, J.B. Sibarita, N. Varin-Blank, L. Velazquez

The adaptor protein APS modulates BCR signalling in mature B cells Cellular Signaling (2020)
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L. Aoun, A. Farutin, N. Garcia-Seyda, P. Negre, M.S. Rizvi, S. Tlili, S. Song, X. Luo, M. Biarnes-Pelicot, R. Galland, J.B. Sibarita, A. Michelot, C. Hivroz, S. Rafai, M.P. Valignat, C. Misbah, O. Theodoly

Amoeboid Swimming Is Propelled by Molecular Paddling in Lymphocytes Biophysical Journal (2020)
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D. Sage, T.A. Pham, H. Babcock, T. Lukes, T. Pengo, J. Chao, R. Velmurugan, A. Herbert, A. Agrawal, S. Colabrese, A. Wheeler, A. Archetti, B. Rieger, R. Ober, G.M. Hagen, J.B. Sibarita, J. Ries, R. Henriques, M. Unser, S. Holden

Super-resolution fight club: assessment of 2D and 3D single-molecule localization microscopy software Nature Methods (2019)
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A. Mehidi, O. Rossier, M. Schaks, A. Chazeau, F. Biname, A. Remorino, M. Coppey, Z. Karatas, J.B. Sibarita, K. Rottner, V. Moreau, G. Giannone

Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion Current Biology (2019)
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F. Levet, G. Julien, R. Galland, C. Butler, A. Beghin, A. Chazeau, P. Hoess, J. Ries, G. Giannone, J.B. Sibarita

A tessellation-based colocalization analysis approach for single-molecule localization microscopy Nature Communications (2019)
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V. Inavalli, M.O. Lenz, C. Butler, J. Angibaud, B. Compans, F. Levet, J. Tonnesen, O. Rossier, G. Giannone, O. Thoumine, E. Hosy, D. Choquet, J.B. Sibarita*, U.V. Nagerl*

A super-resolution platform for correlative live single-molecule imaging and STED microscopy Nature Methods (2019)
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M. Letellier, F. Levet, O. Thoumine, Y. Goda

Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites PLoS Biology (2019)
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